Lumicks – Cell avidity: a new predictor of immune cell function and therapeutic success
June 20, 2023
Affinity between chimeric antigen receptor (CAR) T cells and their target have shown to be a poor predictor for T-cell function. On the contrary,
cell avidity (or overall cellular binding strength) provides a more complete and physiologically relevant picture that reflects the bona fide interaction between T cells and tumor cells. Therefore, this interaction can better predict cellular responses in vivo preclinical models, and drive better, more informed decisions at earlier stages for drug selection and potentially improve clinical outcome.
With the increasing complexity of constructing novel methodologies to further improve clinical outcome, screening methods to quickly identify the best lead candidates is becoming even more essential. One of the main obstacles in the process of measuring avidity as being a critical parameter is the lack of fast, specific, and accurate tool to assess cellular avidity.
The z-Movi® Cell Avidity Analyzer is a novel and unique instrument for direct measurement of cell–cell interaction strength using acoustic forces.
This new technology provides predictive, reproducible, and fast high-throughput results at a single-cell level. We demonstrate, using well-characterized and published set of clinically used CARs, that data obtained with the z-Movi Cell Avidity Analyzer correlates strongly with in vivo functional outcomes compared to traditional in vitro functional assays.
Come by our booth (booth #15) to discover how this new technology has the potential for accelerating the development of cellular immunotherapies against cancer.